Muzi Kuzwayo was born in Paynville, near Springs. He started his schooling at Nolwandle Lower Primary School and finished at Kenneth Masekela High in KwaThema.
He graduated from Rhodes University with a BSc degree in biochemistry and microbiology. After serious soul-searching, he realised that there was no joy to be found in sitting all day and watching germs that cause diarrhoea. He then got into advertising and research working on brands such as Volkswagen, Old Mutual, South African Breweries, Sanlam, Metropolitan Life, Pick n Pay Financial Services, and various Guinness UDV brands.
Having started his writing career in early life by writing his illiterate grandmother's letters as well as those of other illiterate people in his neighbourhood, Muzi went on to write the best-selling books Marketing through Mud and Dust and There is a Tstosi in the Boardroom.
In 2001 he was appointed managing director of TBWA\Hunt\Lascaris Johannesburg and filled the position until 2009.